KAPRUVIA® IS DELIVERED AS A SIMPLE IV BOLUS AT THE END OF HD 1
KAPRUVIA® can be administered as part of your patient’s in-centre HD routine:*1
KAPRUVIA® is administered three times per week at the end of HD treatment†1
The recommended dose of KAPRUVIA® is 0.5 μg/kg dry body weight1
KAPRUVIA® is administered as a simple IV bolus injection into the venous line of the dialysis circuit during rinse-back or after rinse-back‡1
- When given after rinse back, at least 10 mL of sodium chloride
9 mg/mL (0.9%) solution rinse-back volume should be
administered after injection of KAPRUVIA® - If the dose is given during rinse back, no additional sodium
chloride 9 mg/mL (0.9%) solution is needed to flush the line
KAPRUVIA® INJECTION VOLUMES1
| Target Dry Body Weight Range (kg) | Injection Volume (mL) |
|---|---|
| 40 – 44 | 0.4 |
| 45 – 54 | 0.5 |
| 55 – 64 | 0.6 |
| 65 – 74 | 0.7 |
| 75 – 84 | 0.8 |
| 85 – 94 | 0.9 |
| 95 – 104 | 1.0 |
| 105 – 114 | 1.1 |
| 115 – 124 | 1.2 |
| 125 – 134 | 1.3 |
| 135 – 144 | 1.4 |
| 145 – 154 | 1.5 |
| 155 – 164 | 1.6 |
| 165 – 174 | 1.7 |
| 175 – 184 | 1.8 |
| 185 – 194 | 1.9 |
| ≥195 | 2.0 |
The total dose volume (mL) required from the vial should be
calculated as: 0.01 × dry body weight (kg), rounded to the nearest
tenth (0.1 mL).1
Dosing is the same for elderly patients aged ≥65 years as adult
patients.§1
No dose adjustment is required for patients with mild or moderate
hepatic impairment.¶1
- KAPRUVIA® should not be diluted or mixed with other medicinal products
- Vials are for single-use only, discard any unused product
- KAPRUVIA® should be a clear, colourless solution, free from particles. Inspect for any particulate matter or discolouration before administration
